Publications (2016-2021)

Activation-induced marker assays for identification of Trypanosoma cruzi-specific CD4 or CD8 T cells in chronic Chagas disease patients
Ferragut F, Cruz KM, Gallardo JP,Fernández M,Hernández Vasquez Y, Gómez KA
Immunology. 2023 Jun;169(2):185-203. doi: 10.1111/imm.13622.

Expression of Inhibitory Receptors TIGIT, TIM-3, and LAG-3 on CD4+ T Cells from Patients with Different Clinical Forms of Chronic Chagas Disease.
Ferragut F, Alcaraz PB, Beati P, Girard MC, Ossowski MS, Chadi R, Fernández M, Hernández-Vásquez Y, Acevedo GR, Gómez KA.
J Immunol. 2023 Mar 1;210(5):568-579. doi: 10.4049/jimmunol.2200436.

The Kinetoplastid-Specific Protein TcCAL1 Plays Different Roles During In Vitro Differentiation and Host-Cell Invasion in Trypanosoma cruzi.
Rodríguez-Durán J, Gallardo JP, Alba Soto CD, Gómez KA, Potenza M.
Front Cell Infect Microbiol. 2022 Jun 30;12:901880. doi: 10.3389/fcimb.2022.901880.

Galectins in Chagas Disease: A Missing Link Between Trypanosoma cruzi Infection, Inflammation, and Tissue Damage.
Poncini CV, Benatar AF, Gomez KA, Rabinovich GA.
Front Microbiol. 2022 Jan 3;12:794765. doi: 10.3389/fmicb.2021.794765.

In vitro differentiation of Trypanosoma cruzi epimastigotes into metacyclic trypomastigotes using a biphasic medium
Rodríguez Durán J, Muñoz-Calderón A, Gómez KA, Potenza M.
STAR Protocols. 2021. doi: 10.1016/j.xpro.2021.100703

Trypanosoma cruzi induces regulatory B-cell alterations in patients with chronic Chagas disease.
Girard MC, Ossowski MS, Muñoz-Calderón A, Fernández M, Hernández-Vásquez Y, Chadi R, Gómez KA.
Frontiers in Celullar and Infection Microbiology, Front. Cell. Infect. Microbiol. 2021. doi: 10.3389/fcimb.2021.723549

IgE antibodies against Trypanosoma cruzi arginine kinase in patients with chronic Chagas disease.
Valera-Vera EA, Concepción JL, Cáceres AJ, Acevedo GR, Fernández M, Hernández Y, Digirolamo FA, Duschak VG, Soprano LL, Pereira CA, Miranda MR, Gómez KA.
Mol Immunol. 2021. doi: 10.1016/j.molimm.2021.06.024

T cell specificity: a great challenge in Chagas disease.
Ferragut F, Acevedo GR, Gómez KA.
Frontiers in Immunology, 2021. doi: 10.3389/fimmu.2021.674078

Ex vivo characterization of Breg cells in patients with chronic Chagas disease.
Girard MC, Acevedo GR, Ossowski MS, Fernández M, Hernández Y, Chadi R, Gómez KA.
Sci Rep. 2021. doi: 10.1038/s41598-021-84765-x

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system.
Niborskia LL, Potenza M, Chirivi RGS, Simonetti L, Ossowski MS, Grippo V, May M, Staquicinie DI, Parodi-Talice A, Robello C, Comini MA, Alonso GD, Raats JMH, Gómez KA.
EBioMedicine. 2021. doi: 10.1016/j.ebiom.2020.103206

In Silico Guided Discovery of Novel Class I and II Trypanosoma cruzi Epitopes Recognized by T Cells from Chagas’ Disease Patients
Acevedo GR, Juiz NA, Ziblat A, Pérez Perri L, Girard MC, Ossowski MS, Fernández M, Hernández Y, Chadi R, Wittig M, Franke A, Nielsen M, Gómez KA.
J Immunol. 2020 Mar 15;204(6):1571-1581. doi: 10.4049/jimmunol.

T. cruzi infection. Methods in Molecular Biology Book.
Editors: Buscaglia CA and Gomez KA. Publisher: Humana Press; 1st ed. 2019 edition (April 16, 2019); ISBN-10: 1493991477; ISBN-13: 978-1493991471

Generation of T. cruzi-Specific Primary CD4+ T Cell Lines from Peripheral Blood Mononuclear Cells Isolated from Chagas Disease Patients.
Acevedo GR, Alcaráz PB, Pinilla C, Gómez KA.
Methods Mol Biol. 2019;1955:315-337. doi: 10.1007/978-1-4939-9148-8_24

Altered frequency of CD24highCD38high transitional B cells in patients with cardiac involvement of chronic Chagas disease
Girard MC, Acevedo GR, Ossowski MS, Alcaráz PB, Fernández M, Hernández Y, Chadi R, Gómez KA
BioRxiv 2019. doi: https://doi.org/10.1101/684589.

CD4+ T cells from chronic Chagas disease patients with different degrees of cardiac compromise exhibit distinct expression patterns of inhibitory receptors TIGIT, Tim-3 and Lag-3.
Alcaraz PB, Girard MC, Beati P, Chadi R, Fernandez M, Hernandez Y, Gómez KA, Acevedo GR.
BioRxiv 2019. doi: https://doi.org/10.1101/694729

Generation of T. cruzi-Specific Primary CD4+ T Cell Lines from Peripheral Blood Mononuclear Cells Isolated from Chagas Disease Patients. 
Acevedo GR, Alcaráz PB, Pinilla C, Gómez KA. (2019)
Methods Mol Biol. 2019;1955:315-337.

Production of Recombinant Trypanosoma cruzi Antigens in Leishmania tarentolae.
Ferrer MJ, Wehrendt DP, Bonilla M, Comini M, Tellez MT, Potenza M.
T. cruzi Infection – Methods and Protocols, 2019. doi: 10.1007/978-1-4939-9148-8_8

The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease
Acevedo GR, Girard MC, Gómez KA. (2018)
Front. Immunol. August 2018 https://doi.org/10.3389/fimmu.2018.01929

A Panoramic View of the Immune Response to Trypanosoma cruzi Infection. In Chagas Disease: A clinical approach
Acevedo GR, Girard MC, Gómez KA. (2018)
Editors Jaime Marcelo Altcheh, Hector Freilij, Publisher Springer International Publishing, Switzerland, ISBN 978-3-030-00053-0.

Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection
Girard MC, Acevedo GR, López L, Ossowski MS, Piñeyro MD, Grosso JP, Fernandez M, Hernández Vasquez Y, Robello C, Gómez KA. (2018)
Immunology. 2018 Jul 4. doi: 10.1111/imm.12979.

Transcriptome-wide analysis of the Trypanosoma cruzi proliferative cycle identifies the periodically expressed mRNAs and their multiple levels of control.
Chávez S, Eastman G, Smircich P, Becco LL, Oliveira-Rizzo C, Fort R, Potenza M, Garat B, Sotelo-Silveira JR, Duhagon MA. (2017)
PLoS One. 2017 Nov 28;12(11):e0188441

Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients
Acevedo GR, Longhi SA, Bunying A, Sabri N, Atienza A, Zago MP, Santos R, Judkowski VA, Pinilla C, Gómez KA. (2017)
PLoS One. 2017 May 26;12(5):e0178380.

Characterization of TcCYC6 from Trypanosoma cruzi, a gene with homology to mitotic cyclins.
Di Renzo MA, Laverrière M, Schenkman S, Wehrendt DP, Tellez-Iñón MT, Potenza M. (2016)
Parasitol Int. 2016 Jun;65(3):196-204.