Our laboratory is mainly interested in the study of the immune response developed in the infected subjects during the chronic phase of Chagas disease.

Our aim is to elucidate the mechanisms of pathogenesis that lead chronic asymptomatic patients to suffer cardiac disorders, as well as to identify new antigens with projection to the development of prophylactic and / or therapeutic vaccines.

Lab Members

Gonzalo R. Acevedo
Doctoral Fellow CONICET
gacevedo@dna.uba.ar

Lic. Magalí C. Girard
Doctoral Fellow ANCYT-MINCYT
mgirard@dna.uba.ar

Micaela Ossowski
Undergrad Student
micaelaossowski@hotmail.com

Lucas Perez Perri
Undergrad Student
lucas.perezperri@gmail.com

Publications

Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients.
Acevedo GR, Longhi SA, Bunying A, Sabri N, Atienza A, Zago MP, Santos R, Judkowski VA, Pinilla C, Gómez KA. (2017)
PLoS One. 2017 May 26;12(5):e0178380.

Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells.
Benatar AF, García GA, Bua J, Cerliani JP, Postan M, Tasso LM, Scaglione J, Stupirski JC, Toscano MA, Rabinovich GA, Gómez KA.
PLoS Negl Trop Dis. 2015 Oct 9;9(10):e0004148.

Cytokine production but lack of proliferation in peripheral blood mononuclear cells from chronic Chagas’ disease cardiomyopathy patients in response to T. cruzi ribosomal P proteins.
Longhi SA, Atienza A, Perez Prados G, Buying A, Balouz V, Buscaglia CA, Santos R, Tasso LM, Bonato R, Chiale P, Pinilla C, Judkowski VA, Gómez KA.
PLoS Negl Trop Dis. 2014 Jun 5;8(6):e2906.

Evaluation of in-house ELISA using Trypanosoma cruzi lysate and recombinant antigens for diagnosis of Chagas disease and discrimination of its clinical forms.
Longhi SA, Brandariz SB, Lafon SO, Niborski LL, Luquetti AO, Schijman AG, Levin MJ, Gómez KA.
Am J Trop Med Hyg. 2012 Aug;87(2):267-71.

Antibodies against the Trypanosoma cruzi ribosomal P proteins induce apoptosis in HL-1 cardiac cells.
Levy GV, Tasso LM, Longhi SA, Rivello HG, Kytö V, Saukko P, Levin MJ, Gómez KA.
Int J Parasitol. 2011 May;41(6):635-44.

Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2β protein: implications in cross-reactivity.
Pizarro JC, Boulot G, Bentley GA, Gómez KA, Hoebeke J, Hontebeyrie M, Levin MJ, Smulski CR.
PLoS Negl Trop Dis. 2011 Nov;5(11):e1375.

Human recombinant antibodies against Trypanosoma cruzi ribosomal P2β protein.
Grippo V, Niborski LL, Gomez KA, Levin MJ.
Parasitology. 2011 May;138(6):736-47.

Ex Lab Members

Leticia L. Niborski Ph.D.
Institut Curie, PSL Research University, INSERM U932, SiRIC Translational Immunotherapy Team, Paris F-75005, Paris, France

Alejandro F. Benatar Ph.D.
INGEBI-CONICET

Laura Tasso
Instituto Nacional de Parasitología “Dr. Mario Fatala Chaben”

  • Bioquímica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. 1990.
  • Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. 1992.
  • Doctora, Universidad de Buenos Aires. 1998.
  • Independent Researcher CONICET. 2005 – cont.
  • Secretaria de la Sociedad Argentina de Protozoología. 2016 – 2018.